| 1 | Port St. Lucie city (southwest 4) | 16,198 |
| 2 | Port St. Lucie city (south-southeast 1) | 13,631 |
| 3 | Fort Pierce city (southwest 2) | 9,539 |
| 4 | Port St. Lucie city (north 1) | 9,121 |
| 5 | Port St. Lucie city (south-southeast 2) | 8,987 |
| 6 | Port St. Lucie city (south 2) | 8,913 |
| 7 | Port St. Lucie city (north 2) | 8,270 |
| 8 | Port St. Lucie city (southwest 1) | 7,861 |
| 9 | Fort Pierce city (south-southwest) | 7,830 |
| 10 | Port St. Lucie city (east 3) | 7,580 |
| 11 | Port St. Lucie city (south-southwest) | 7,578 |
| 12 | Port St. Lucie city (southwest 3) | 7,268 |
| 13 | Fort Pierce city (southwest 1) | 7,223 |
| 14 | Port St. Lucie city (south-southeast 3) | 7,080 |
| 15 | Fort Pierce city (east-southeast) | 7,050 |
| 16 | Port St. Lucie city (east 1) | 6,903 |
| 17 | Port St. Lucie city (southeast 1) | 6,609 |
| 18 | White City CDP | 6,406 |
| 19 | Port St. Lucie city (east-southeast 2) | 6,379 |
| 20 | Port St. Lucie city (east 4) | 6,122 |
| 21 | Port St. Lucie city (northeast 1) | 6,055 |
| 22 | Port St. Lucie city (south 1) | 6,005 |
| 23 | Port St. Lucie city (northwest 1) | 5,845 |
| 24 | Port St. Lucie city (east 2) | 5,770 |
| 25 | Port St. Lucie city (east-southeast 1) | 5,737 |
| 26 | Indian River Estates CDP (southeast) | 5,585 |
| 27 | Fort Pierce city (northwest) | 5,516 |
| 28 | Port St. Lucie city (southwest 2) | 5,480 |
| 29 | Indian River Estates CDP (northwest 1) | 5,286 |
| 30 | Fort Pierce North CDP | 5,256 |
| 31 | Port St. Lucie city (west-southwest 2) | 5,207 |
| 32 | Port St. Lucie city (southeast 2) | 5,179 |
| 33 | Port St. Lucie city (west-northwest 3) | 4,998 |
| 34 | Port St. Lucie city (northwest 2) | 4,892 |
| 35 | Fort Pierce city (southeast) | 4,535 |
| 36 | Port St. Lucie city (north 3) | 4,516 |
| 37 | Port St. Lucie city (west-southwest 1) | 4,459 |
| 38 | Port St. Lucie city (west-northwest 1) | 4,195 |
| 39 | Port St. Lucie city (north-northwest 1) | 4,155 |
| 40 | Port St. Lucie city (east 5) | 4,143 |
| 41 | Fort Pierce city (east) | 4,073 |
| 42 | Port St. Lucie city (west) | 4,031 |
| 43 | Port St. Lucie city (north-northeast) | 4,010 |
| 44 | Unincorporated (southeast) | 3,753 |
| 45 | Fort Pierce city (south-southeast) | 3,682 |
| 46 | Fort Pierce city (north 2) | 3,580 |
| 47 | Port St. Lucie city (north 4) | 3,527 |
| 48 | Fort Pierce city (west) | 3,515 |
| 49 | Unincorporated (west-northwest) | 3,502 |
| 50 | Fort Pierce city (north 1) | 3,494 |
| 51 | Lakewood Park CDP (west 1) | 3,458 |
| 52 | Port St. Lucie city (east-northeast 2) | 3,367 |
| 53 | Port St. Lucie city (west-northwest 2) | 3,133 |
| 54 | Lakewood Park CDP (east-southeast) | 3,065 |
| 55 | Port St. Lucie city (northeast 2) | 3,034 |
| 56 | Lakewood Park CDP (west 2) | 2,886 |
| 57 | Fort Pierce city (north 3) | 2,862 |
| 58 | Lakewood Park CDP (east-northeast) | 2,656 |
| 59 | Port St. Lucie city (north-northwest 2) | 2,495 |
| 60 | Hutchinson Island South CDP (south-southeast) | 2,363 |
| 61 | Lakewood Park CDP (west 3) | 2,163 |
| 62 | Hutchinson Island South CDP (south) | 1,987 |
| 63 | Port St. Lucie city (east-northeast 1) | 1,885 |
| 64 | St. Lucie Village town | 1,772 |
| 65 | Indian River Estates CDP (northwest 2) | 1,598 |
| 66 | Fort Pierce city (north-northeast) | 984 |